Donor T cell-derived TNF is required for graft-versus-host disease.

2003 MAY 6 - (NewsRx.com & NewsRx.net) -- Donor T cell-derived TNF is required for graft-versus-host disease after bone marrow transplantation.

According to published research from the United States, "Previous studies in murine bone marrow transplantation (BMT) models using neutralizing anti-tumor necrosis factor (TNF) antibodies or TNF receptor (TNFR) deficient recipients have demonstrated that TNF can be involved in both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL).

"TNF in these GVHD and GVL models was thought to be produced primarily by activated monocytes and macrophages, and the role of T cell-derived TNF was not determined. We used …